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FG-3019

Cat. No. M25302
FG-3019 Structure
Synonym:

Pamrevlumab; Anti-Human CTGF Recombinant Antibody

Size Price Availability Quantity
100ug USD 600  USD600 In stock
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Quality Control & Documentation
Biological Activity

FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF).

Chemical Information
CAS Number 946415-13-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yi-Wen Shen, et al. Trends Cancer. Targeting CTGF in Cancer: An Emerging Therapeutic Opportunity

[2] Giacomo Sgalla, et al. Expert Opin Investig Drugs. Pamrevlumab for the treatment of idiopathic pulmonary fibrosis

[3] Hélène Kaplon, et al. MAbs. Antibodies to watch in 2020

[4] Luca Richeldi, et al. Lancet Respir Med. Pamrevlumab, an anti-connective tissue growth factor therapy, for idiopathic pulmonary fibrosis (PRAISE): a phase 2, randomised, double-blind, placebo-controlled trial

[5] Mitchell C Brenner, et al. Pharm Res. FG-3019, a Human Monoclonal Antibody Recognizing Connective Tissue Growth Factor, is Subject to Target-Mediated Drυg Disposition

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Keywords: FG-3019, Pamrevlumab; Anti-Human CTGF Recombinant Antibody supplier, Apoptosis, inhibitors, activators


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