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ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation.
| Molecular Weight | 353.48 |
| Formula | C20H23N3OS |
| CAS Number | 301177-43-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | 4°C, protect from light |
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