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Elocalcitol

Cat. No. M29090
Elocalcitol Structure
Synonym:

BXL-628; Ro-26-9228

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Quality Control & Documentation
Biological Activity

Elocalcitol (BXL-628) is a selective, orally active vitamin D receptor (VDR) agonist. Elocalcitol shows anti-inflammatory activity. Elocalcitol inhibits growth of prostate cancer cells.

Chemical Information
Molecular Weight 442.65
Formula C29H43FO2
CAS Number 199798-84-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tomi Streng, et al. BJU Int. Effects on bladder function of combining elocalcitol and tolterodine in rats with outflow obstruction

[2] Atul Tiwari. IDrugs. Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder and male infertility

[3] Atul Tiwari. Expert Opin Investig Drugs. Elocalcitol (BXL-628): a novel, investigational therapy for the therapeutic management of benign prostatic hyperplasia

[4] E Borgogni, et al. Endocrinology. Elocalcitol inhibits inflammatory responses in human thyroid cells and T cells

[5] M Maggi, et al. J Endocrinol Invest. Pre-clinical evidence and clinical translation of benign prostatic hyperplasia treatment by the vitamin D receptor agonist BXL-628 (Elocalcitol)

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Keywords: Elocalcitol, BXL-628; Ro-26-9228 supplier, Vitamin, inhibitors, activators


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