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Eldecalcitol is an analog of 1,25-dihydroxyvitamin D3 that improves bone mineral density. Eldecalcitol is orally bioactive, which binds to vitamin D receptors and binding protein for the goal of achieving greater specificity to bind calcium for its absorption. This greater affinity is 2.7-fold that of the active vitamin D form of calcitriol. Eldecalcitol (0-50 nM; 24 h) displays no cytotoxicity, and (0.5-50 nM; 24 h) reduces cell death induced by LPS (5 μg/mL). Eldecalcitol (5 nM; 24 h) inhibits the LPS-induced pyroptosis by activating Nrf2 and its effector molecule HO-1. Eldecalcitol (0.5-50 nM; 24 h) exhibits anti-pyroptotic ability, and decreases NLRP3, caspase-1, and IL-1β expression dose-dependently. Eldecalcitol (0.04-40 nM; 0-48 h) inhibits the proliferation and migration of SCC-15 and CAL-27 cells.
| Molecular Weight | 490.72 |
| Formula | C30H50O5 |
| CAS Number | 104121-92-8 |
| Solubility (25°C) | Methanol 8 mg/mL DMSO 3 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | 4°C, protect from light, sealed |
[3] Yuko Noguchi, et al. Eldecalcitol for the treatment of osteoporosis
[4] T Matsumoto, et al. Eldecalcitol for the treatment of osteoporosis
[5] Mark Sanford, et al. Eldecalcitol: a review of its use in the treatment of osteoporosis
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