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Cat. No. M9189
Eldecalcitol Structure

ED-71; Edirol; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3

Size Price Availability Quantity
10mg USD 1180  USD1180 In stock
25mg USD 2350  USD2350 In stock
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Quality Control & Documentation
Biological Activity

Eldecalcitol is an analog of 1,25-dihydroxyvitamin D3 that improves bone mineral density. Eldecalcitol is orally bioactive, which binds to vitamin D receptors and binding protein for the goal of achieving greater specificity to bind calcium for its absorption. This greater affinity is 2.7-fold that of the active vitamin D form of calcitriol. Eldecalcitol (0-50 nM; 24 h) displays no cytotoxicity, and (0.5-50 nM; 24 h) reduces cell death induced by LPS (5 μg/mL). Eldecalcitol (5 nM; 24 h) inhibits the LPS-induced pyroptosis by activating Nrf2 and its effector molecule HO-1. Eldecalcitol (0.5-50 nM; 24 h) exhibits anti-pyroptotic ability, and decreases NLRP3, caspase-1, and IL-1β expression dose-dependently. Eldecalcitol (0.04-40 nM; 0-48 h) inhibits the proliferation and migration of SCC-15 and CAL-27 cells.

Chemical Information
Molecular Weight 490.72
Formula C30H50O5
CAS Number 104121-92-8
Solubility (25°C) Methanol 8 mg/mL
DMSO 3 mg/mL (ultrasonic and warming and heat to 60°C)
Storage 4°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Cancan Huang, et al. Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway

[2] Hitoshi Saito, et al. Eldecalcitol replaces endogenous calcitriol but does not fully compensate for its action in vivo

[3] Yuko Noguchi, et al. Eldecalcitol for the treatment of osteoporosis

[4] T Matsumoto, et al. Eldecalcitol for the treatment of osteoporosis

[5] Mark Sanford, et al. Eldecalcitol: a review of its use in the treatment of osteoporosis

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Abmole Inhibitor Catalog

Keywords: Eldecalcitol, ED-71; Edirol; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 supplier, Vitamin, inhibitors, activators

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