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EB1089

Cat. No. M8638

All AbMole products are for research use only, cannot be used for human consumption.

EB1089 Structure
Synonym:

EB 1089

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Quality Control & Documentation
Biological Activity

EB1089 is a Vitamin D analog 50 to 200 times more potent than Vitamin D in inhibiting growth and inducing differentiation with half the hypercalcemic activity. Studies have found EB1089 to be more potent than vitamin D in inhibiting growth and inducing differentiation of some cancer cell lines. EB1089 enhances radio sensitivity of H460 and A549 non-small cell lung cancer (NSCLC) cells.

Chemical Information
Molecular Weight 454.68
Formula C30H46O3
CAS Number 134404-52-7
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Johan Lundqvist, et al. Vitamin D analog EB1089 inhibits aromatase expression by dissociation of comodulator WSTF from the CYP19A1 promoter-a new regulatory pathway for aromatase

[2] Vandanajay Bhatia, et al. EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells

[3] Lianjun Lu, et al. Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57

[4] Erin L Milliken, et al. EB1089, a vitamin D receptor agonist, reduces proliferation and decreases tumor growth rate in a mouse model of hormone-induced mammary cancer

[5] S Y James, et al. EB1089, a synthetic analogue of vitamin D, induces apoptosis in breast cancer cells in vivo and in vitro

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Abmole Inhibitor Catalog




Keywords: EB1089, EB 1089 supplier, inhibitors, activators

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