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Drozitumab

Cat. No. M25283
Drozitumab Structure
Synonym:

PRO 95780; rhuMAb-DR 5 Anti-Human DR5 Recombinant Antibody

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Quality Control & Documentation
Biological Activity

Drozitumab (PRO 95780) is a human agonistic monoclonal antibody which binds the death receptor DR5. Drozitumab has potent antitumor activity against rhabdomyosarcoma.

Chemical Information
CAS Number 912628-39-8
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jeongsup Shim, et al. J Immunol Methods. Development of a bioassay as a measure of drozitumab-mediated apoptosis induced by soluble Fc gamma receptors

[2] Jennifer L Dine, et al. Breast Cancer Res Treat. The TRAIL receptor agonist drozitumab targets basal B triple-negative breast cancer cells that express vimentin and Axl

[3] Irene Zinonos, et al. Anticancer Res. Doxorubicin overcomes resistance to drozitumab by antagonizing Inhibitor of Apoptosis Proteins (IAPs)

[4] Kathleen I Pishas, et al. Oncol Rep. Pre-activation of the p53 pathway through Nutlin-3a sensitises sarcomas to drozitumab therapy

[5] Zhigang Kang, et al. Clin Cancer Res. Drozitumab, a human antibody to death receptor 5, has potent antitumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response

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Keywords: Drozitumab, PRO 95780; rhuMAb-DR 5 Anti-Human DR5 Recombinant Antibody supplier, Apoptosis, inhibitors, activators


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