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Disitamab vedotin

Cat. No. M24941

All AbMole products are for research use only, cannot be used for human consumption.

Disitamab vedotin Structure
Synonym:

RC48

Size Price Availability
5mg USD 850  USD850 3-4 Weeks
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Quality Control & Documentation
Biological Activity

Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE). Disitamab vedotin enhances antitumor immunity.

Chemical Information
CAS Number 2136633-23-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Yixuan Hu, et al. Drugs Today (Barc). Disitamab vedotin, a novel HER2-directed antibody-drυg conjugate in gastric cancer and other solid tumors

[2] Fan Shi, et al. Drug Deliv. Disitamab vedotin: a novel antibody-drυg conjugates for cancer therapy

[3] Hélène Kaplon, et al. MAbs. Antibodies to watch in 2022

[4] Emma D Deeks. Drugs. Disitamab Vedotin: First Approval

[5] Jing Jiang, et al. Toxicol Lett. Preclinical safety profile of disitamab vedotin:a novel anti-HER2 antibody conjugated with MMAE

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MC-SN38 is a agent-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody agent conjugate (ADC).

DM4-SMCC 

DM4-SMCC is a agent-linker conjugate for ADC with antitumor activity by using DM4 (an antitubulin agent), linked via the non-cleavable SMCC linker.

Lys-SMCC-DM1

Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization.

Doxorubicin-SMCC 

Doxorubicin-SMCC is a agent-linker conjugate for ADC.

Mal-PEG4-VC-PAB-DMEA-PNU-159682 

Mal-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682.

  Catalog
Abmole Inhibitor Catalog




Keywords: Disitamab vedotin, RC48 supplier, Drug-Linker Conjugates for ADC, inhibitors, activators

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