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DIPQUO

Cat. No. M14488
DIPQUO Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

DIPQUO is an activator of the bone marker alkaline phosphatase (ALP), with an EC50 of 6.27 μM in C2C12 cells. DIPQUO promotes mouse and human osteoblast differentiation via activation of p38 MAPK-β.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 315.37
Formula
CAS Number 1269365-82-3
Purity >99%
Solubility DMSO 5 mg/mL (ultrasonic and warming and heat to 60°C)
Storage at -20°C
References

[1] Hong-Lin Zhu, et al. Diaqua-bis-(l-lactato)magnesium

[2] Hui-Feng Zhang, et al. Poly[diaqua-(μ(4)-benzene-1,2,4,5-tetra-carboxyl-ato)[μ(2)-1,4-bis-(3-pyridyl-meth-yl)piperazine]dizinc(II)]

[3] Xia Li, et al. trans-Diaqua-bis-[5-carb-oxy-4-carboxyl-ato-2-(4-pyridinio)-1H-imidazol-1-ido-κN,O]zinc(II)

[4] Guohua Xia, et al. Diaqua-bis(pyridine-2-carboxyl-ato-κN,O)iron(II)

[5] Feng-Jie Cheng, et al. Diaqua-[3,5-bis-(4-pyrid-yl)-1H-1,2,4-triazole-κN](pyridine-2,6-dicarboxyl-ato-κO,N,O)nickel(II)

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  Catalog
Abmole Inhibitor Catalog




Keywords: DIPQUO supplier, Phosphatase, inhibitors

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