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Dimethoxycurcumin

Cat. No. M28655
Dimethoxycurcumin Structure
Synonym:

DiMC; CHC 004; Di-O-methylcurcumin

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Biological Activity

Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities.

Chemical Information
Molecular Weight 396.43
Formula C23H24O6
CAS Number 160096-59-3
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Muhammad Sohail, et al. Drug Deliv. Complex polymeric nanomicelles co-delivering doxorubicin and dimethoxycurcumin for cancer chemotherapy

[2] Muhammad Sohail, et al. Front Pharmacol. A Promising Anticancer Agent Dimethoxycurcumin: Aspects of Pharmacokinetics, Efficacy, Mechanism, and Nanoformulation for Drug Delivery

[3] Thalita Alves Zanetti, et al. Chem Biol Interact. Dimethoxycurcumin reduces proliferation and induces apoptosis in renal tumor cells more efficiently than demethoxycurcumin and curcumin

[4] Manouchehr Teymouri, et al. J Cell Physiol. Biological and pharmacological evaluation of dimethoxycurcumin: A metabolically stable curcumin analogue with a promising therapeutic potential

[5] Amit Kunwar, et al. Free Radic Res. Differential antioxidant/pro-oxidant activity of dimethoxycurcumin, a synthetic analogue of curcumin

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Keywords: Dimethoxycurcumin, DiMC; CHC 004; Di-O-methylcurcumin supplier, NO Synthase, inhibitors, activators

 
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