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DHODH-IN-14

Cat. No. M54625

All AbMole products are for research use only, cannot be used for human consumption.

DHODH-IN-14 Structure

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Quality Control & Documentation
Biological Activity

DHODH-IN-14 is a hydroxyfurazan analog of A771726 and a dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 0.49 μM for hepatic DHODH in rats.DHODH-IN-14 can be used in rheumatoid arthritis-related studies.

Chemical Information
Molecular Weight 353.00
Formula C15H7F4N3O3
CAS Number 1364791-93-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Related DHODH Products
Teriflunomide

Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.

Vidofludimus

Vidofludimus (4SC-101; SC12267) is an immunosuppressant that inhibits DHODH and inhibits il-17 secretion without affecting lymphocyte proliferation.

Brequinar

Brequinar is an effective Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 5.2 nM for human DHODH, and a broad-spectrum antiviral agent.

Orludodstat  (BAY-2402234)

BAY-2402234 is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies, with an IC50 of 1.2 nM.

AG-636

AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor,IC50 17 nM. AG-636 has strong anti-cancer effects.

  Catalog
Abmole Inhibitor Catalog




Keywords: DHODH-IN-14 supplier, DHODH, inhibitors, activators

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