| Cat.No. | Name | Information |
|---|---|---|
| M54621 | DHODH-IN-23 | DHODH-IN-23 is an orally active dihydroorotic acid dehydrogenase (DHODH) inhibitor for cancer-related studies. |
| M54620 | hDHODH-IN-1 | hDHODH-IN-1 is a human dihydroorotic acid dehydrogenase (hDHODH) inhibitor with anti-inflammatory activity. hDHODH-IN-1 is a human dihydroorotic acid dehydrogenase inhibitor with anti-inflammatory activity. |
| M30079 | PfDHODH-IN-2 | PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria. |
| M28093 | DHODH-IN-11 | DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03. |
| M20800 | ASLAN003 | ASLAN003 (LAS 186323) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors. |
| M20779 | Brequinar Sodium | Brequinar Sodium (Bipenquinate, BRQ, DUP-785, NSC 368390) is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of ~20 nM and triggers differentiation in the ER-HoxA9, U937, and THP1 cells with ED50 of ~1 μM. |
| M20621 | ML390 | ML390 is a human dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 value of 0.56 μM.Additionally, ML390 is an inducer of myeloid differentiation in acute myeloid leukemia (AML) cells. |
| M18400 | Ginkgolic Acid C17:2 | Ginkgolic Acid C17:2 targets human dihydroorotic acid dehydrogenase (DHODH). |
| M17443 | Lapachol | Lapachol is a naturally occurring naphthoquinone and orally active, potent inhibitor of dihydroorotic acid dehydrogenase (DHODH).Lapachol has immunosuppressive activity against lymphocytes by inhibiting pyrimidine synthesis through direct blockade of DHODH activity. In addition, Lapachol is a vitamin K antagonist with antitumor and antileishmanial activity that inhibits DNA and RNA synthesis in tumor cells. |
| M10776 | AG-636 | AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor,IC50 17 nM. AG-636 has strong anti-cancer effects. |
| M9647 | Orludodstat (BAY-2402234) | BAY-2402234 is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies, with an IC50 of 1.2 nM. |
| M6280 | Brequinar | Brequinar is an effective Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 5.2 nM for human DHODH, and a broad-spectrum antiviral agent. |
| M4876 | Vidofludimus | Vidofludimus (4SC-101; SC12267) is an immunosuppressant that inhibits DHODH and inhibits il-17 secretion without affecting lymphocyte proliferation. |
| M3059 | Teriflunomide | Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent. |
| M2229 | Leflunomide | Leflunomide (HWA486) is an inhibitor of dihydroorotate dehydrogenase with IC50 of 2.5 μM. |
| M54630 | DHODH-IN-13 | DHODH-IN-13 is a hydroxyfurazan analog of A771726 and a dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for hepatic DHODH in rats.DHODH-IN-13 can be used in rheumatoid arthritis-related studies. |
| M54629 | DHODH-IN-12 | DHODH-IN-12 is a Leflunomide derivative and a weak inhibitor of dihydroorotic acid dehydrogenase (DHODH), with a pKa of 5.07. |
| M54628 | hDHODH-IN-5 | hDHODH-IN-5 is a human dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 0.91 μM. hDHODH-IN-7 induces differentiation of acute myeloid leukemia cells. |
| M54626 | DHODH-IN-8 | DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotic acid dehydrogenase (DHODH) with IC50s of 0.13 μM and 47.4 μM and Ki of 0.016 μM and 5.6 μM, respectively.DHODH-IN-8 exhibits antimalarial activity. |
| M54625 | DHODH-IN-14 | DHODH-IN-14 is a hydroxyfurazan analog of A771726 and a dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 0.49 μM for hepatic DHODH in rats.DHODH-IN-14 can be used in rheumatoid arthritis-related studies. |
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