About 19 results found for searched term "DHODH" (0.095 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M28093 | DHODH-IN-11 | DHODH |
| DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03. | ||
| M54613 | DHODH-IN-16 | DHODH |
| DHODH-IN-16 is a potent dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH. | ||
| M29652 | DHODH-IN-21 | Dehydrogenase |
| DHODH-IN-21 (compound 19) is an orally active selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 1.1 nM. DHODH-IN-21 has anticancer activity and can be used in studies of acute myeloid leukaemia (AML). | ||
| M30079 | PfDHODH-IN-2 | DHODH |
| PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria. | ||
| M54614 | hDHODH-IN-4 | DHODH |
| hDHODH-IN-4 is a potent inhibitor of human dihydroorotic acid dehydrogenase (DHODH) with a pIC50 of 7.8 for inhibition of human recombinant DHODH. hDHODH-IN-4 inhibits measles virus replication with a pMIC50 of 8.8. hDHODH-IN-4 is a potent inhibitor of human recombinant DHODH. | ||
| M54629 | DHODH-IN-12 | DHODH |
| DHODH-IN-12 is a Leflunomide derivative and a weak inhibitor of dihydroorotic acid dehydrogenase (DHODH), with a pKa of 5.07. | ||
| M54626 | DHODH-IN-8 | DHODH |
| DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotic acid dehydrogenase (DHODH) with IC50s of 0.13 μM and 47.4 μM and Ki of 0.016 μM and 5.6 μM, respectively.DHODH-IN-8 exhibits antimalarial activity. | ||
| M54625 | DHODH-IN-14 | DHODH |
| DHODH-IN-14 is a hydroxyfurazan analog of A771726 and a dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 0.49 μM for hepatic DHODH in rats.DHODH-IN-14 can be used in rheumatoid arthritis-related studies. | ||
| M54624 | DHODH-IN-4 | DHODH |
| DHODH-IN-4 is a dihydroorotic acid dehydrogenase (DHODH) inhibitor of human and Plasmodium falciparum, with IC50 values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively.DHODH-IN-4 exhibits anti-malarial activity. | ||
| M54621 | DHODH-IN-23 | DHODH |
| DHODH-IN-23 is an orally active dihydroorotic acid dehydrogenase (DHODH) inhibitor for cancer-related studies. | ||
| M54616 | DHODH-IN-17 | DHODH |
| DHODH-IN-17 is a 2-anilinoylnicotinic acid and an inhibitor of human dihydroorotic acid dehydrogenase (DHODH) (IC50=0.40 μM).DHODH-IN-17 can be used in studies related to acute myeloid leukemia (AML). | ||
| M54630 | DHODH-IN-13 | DHODH |
| DHODH-IN-13 is a hydroxyfurazan analog of A771726 and a dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for hepatic DHODH in rats.DHODH-IN-13 can be used in rheumatoid arthritis-related studies. | ||
| M54628 | hDHODH-IN-5 | DHODH |
| hDHODH-IN-5 is a human dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 0.91 μM. hDHODH-IN-7 induces differentiation of acute myeloid leukemia cells. | ||
| M54623 | DHODH-IN-15 | DHODH |
| DHODH-IN-15 is a Hydroxyfurazan analog of A771726 and a dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH.DHODH-IN-15 may be useful for rheumatoid arthritis related studies. | ||
| M54622 | hDHODH-IN-7 | DHODH |
| hDHODH-IN-7 is a human dihydroorotic acid dehydrogenase (DHODH) inhibitor with concomitant antiviral activity and a pMIC50 of 7.4. | ||
| M54620 | hDHODH-IN-1 | DHODH |
| hDHODH-IN-1 is a human dihydroorotic acid dehydrogenase (hDHODH) inhibitor with anti-inflammatory activity. hDHODH-IN-1 is a human dihydroorotic acid dehydrogenase inhibitor with anti-inflammatory activity. | ||
| M54619 | hDHODH-IN-3 | DHODH |
| hDHODH-IN-3 is a human dihydroorotic acid dehydrogenase (HsDHODH) inhibitor that inhibits measles virus replication with a pMIC50 value of 8.6. | ||
| M54618 | DHODH-IN-1 | DHODH |
| DHODH-IN-1 is a potent dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. In addition, DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway. | ||
| M54612 | hDHODH-IN-13 | DHODH |
| hDHODH-IN-13 is an inhibitor of human dihydroorotic acid dehydrogenase (hDHODH) with an IC50 value of 173.4 nM. hDHODH-IN-13 can be used in studies related to inflammatory bowel disease (IBD). | ||
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