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Deoxythymidine-5'-triphosphate

Cat. No. M29998
Deoxythymidine-5'-triphosphate Structure
Synonym:

dTTP

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Biological Activity

Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.

Chemical Information
Molecular Weight 482.17
Formula C10H17N2O14P3
CAS Number 365-08-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jiao Zhang, et al. J Microbiol Biotechnol. Enzymatic Manufacture of Deoxythymidine-5'-Triphosphate with Permeable Intact Cells of E. coli Coexpressing Thymidylate Kinase and Acetate Kinase

[2] M Tanaka, et al. Cancer Res. Utilization of 5-fluoro-2'-deoxyuridine triphosphate and 5-fluoro-2'-deoxycytidine triphosphate in DNA synthesis by DNA polymerases alpha and beta from calf thymus

[3] W H Prusoff, et al. Chem Biol Interact. Regulation of thymidine kinase activity by 5-iodo-2'-deoxyuridine 5'-triphosphate and deoxythymidine 5'-triphosphate

[4] J E Reardon, et al. J Biol Chem. Human immunodeficiency virus reverse transcriptase. Substrate and inhibitor kinetics with thymidine 5'-triphosphate and 3'-azido-3'-deoxythymidine 5'-triphosphate

[5] P Huang, et al. J Biol Chem. Selective action of 3'-azido-3'-deoxythymidine 5'-triphosphate on viral reverse transcriptases and human DNA polymerases

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Keywords: Deoxythymidine-5'-triphosphate, dTTP supplier, DNA/RNA Synthesis, inhibitors, activators

 
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