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DCA (Sodium dichloroacetate) is a inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo.
Patent. CN116570580A 2023 Aug 11.
Patent. CN116570580A
DCA purchased from AbMole
| Molecular Weight | 150.92 |
| Formula | C2HCl2NaO2 |
| CAS Number | 2156-56-1 |
| Solubility (25°C) | Water 60 mg/mL DMSO 15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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