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KY-556 (N-556) is a promising and orally-active pro-agent of disodium cromoglycate (DSCG) against allergic diseases.
KY-556 (N-556) (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats.
| Molecular Weight | 725.57 |
| Formula | C33H38Cl2N2O12 |
| CAS Number | 110816-78-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 75 mg/mL |
| Storage | 4°C, dry, sealed |
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