Free shipping on all orders over $ 500

DB818 

Cat. No. M30614

All AbMole products are for research use only, cannot be used for human consumption.

DB818  Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

DB818 is a potent inhibitor of Homeobox A9 (HOXA9). HOXA9 is a transcription factor regulating haematopoiesis and leukaemia cell proliferation, involving in acute myeloid leukaemia (AML). DB818 inhibits AML cell lines growth, induces apoptosis.

Chemical Information
Molecular Weight 360.44
Formula C19H16N6S
CAS Number 790241-43-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Yuri Sonoda, et al. Anticancer Res. Effects of HOXA9 Inhibitor DB818 on the Growth of Acute Myeloid Leukaemia Cells

[2] Sabine Depauw, et al. J Med Chem. Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model

[3] W David Wilson, et al. Curr Med Chem Anticancer Agents. Dications that target the DNA minor groove: compound design and preparation, DNA interactions, cellular distribution and biological activity

Related Apoptosis Products
Coenzyme Q0

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance.

C6 Ceramide

C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway.

DB2115 tertahydrochloride

DB2115 tertahydrochloride is a potent inhibitor of myeloid master regulator PU.1. DB2115 tertahydrochloride has the potential for researching cancers, including hematologic cancers.

14-3-3η Protein inhibitor 1

14-3-3η Protein inhibitor 1 is a 14-3-3η protein inhibitor with a KD of 35 µM.

Deferoxamine

Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells.

  Catalog
Abmole Inhibitor Catalog




Keywords: DB818  supplier, Apoptosis, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.