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Dansylcadaverine

Cat. No. M9539
Dansylcadaverine Structure
Synonym:

Monodansyl cadaverine

Size Price Availability Quantity
25mg USD 40  USD40 In stock
50mg USD 60  USD60 In stock
100mg USD 95  USD95 In stock
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Quality Control & Documentation
Biological Activity

Dansylcadaverine (Dansylcadaverine) is an autofluorescent compound used to label autophagic vacuoles.Dansylcadaverine is a high-affinity substrate for glutamine transaminases and blocks receptor-mediated endocytosis of a variety of ligands.

Chemical Information
Molecular Weight 335.46
Formula C17H25N3O2S
CAS Number 10121-91-2
Solubility (25°C) DMSO ≥ 35 mg/mL
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] T Huff, et al. FEBS Lett. Thymosin beta(4) Serves as a Glutaminyl Substrate of Transglutaminase. Labeling With Fluorescent Dansylcadaverine Does Not Abolish Interaction With G-actin.

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