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Dalazatide

Cat. No. M27762

All AbMole products are for research use only, cannot be used for human consumption.

Dalazatide Structure
Synonym:

ShK-186

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Quality Control & Documentation
Biological Activity

Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease.

Chemical Information
Molecular Weight 4442.08
Formula C184H296N57O55PS7
CAS Number 1081110-69-1
Solubility (25°C) Water
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Anu Tyagi, et al. Proc Natl Acad Sci U S A. Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drυg

[2] Gabor Tajti, et al. Biochem Pharmacol. The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides

[3] Qiwen Liao, et al. Drug Discov Today. Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease

[4] Peter J Prentis, et al. Toxins (Basel). Sea Anemones: Quiet Achievers in the Field of Peptide Toxins

[5] Eric J Tarcha, et al. PLoS One. Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

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Keywords: Dalazatide, ShK-186 supplier, Potassium Channel, inhibitors, activators

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