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Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release and the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling. Cynaropicrin has IC50 values of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin strongly inhibited TNF-alpha release from lipopolysaccharide-stimulated murine macrophage, RAW264.7 cells, and differentiated human macrophage, U937 cells. It also potently attenuated the accumulation of NO released from lipopolysaccharide- and interferon-gamma-stimulated RAW264.7 cells in a dose-dependent manner.
| Molecular Weight | 346.37 |
| Formula | C19H22O6 |
| CAS Number | 35730-78-0 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage | -20°C, protect from light, sealed |
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