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Cynaropicrin

Cat. No. M10324
Cynaropicrin Structure
Size Price Availability
5mg USD 250  USD250 4-7 Days
10mg USD 450  USD450 4-7 Days
25mg USD 750  USD750 4-7 Days
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Quality Control & Documentation
Biological Activity

Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release and the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling. Cynaropicrin has IC50 values of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin strongly inhibited TNF-alpha release from lipopolysaccharide-stimulated murine macrophage, RAW264.7 cells, and differentiated human macrophage, U937 cells. It also potently attenuated the accumulation of NO released from lipopolysaccharide- and interferon-gamma-stimulated RAW264.7 cells in a dose-dependent manner.

Chemical Information
Molecular Weight 346.37
Formula C19H22O6
CAS Number 35730-78-0
Solubility (25°C) DMSO 50 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Teruaki Masutani, et al. Life Sci. Cynaropicrin is dual regulator for both degradation factors and synthesis factors in the cartilage metabolism

[2] Cristiane Franca da Silva, et al. Antimicrob Agents Chemother. Activities of psilostachyin A and cynaropicrin against Trypanosoma cruzi in vitro and in vivo

[3] J Y Cho, et al. Eur J Pharmacol. In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa

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