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Cycloheximide

Cat. No. M4879

All AbMole products are for research use only, cannot be used for human consumption.

Cycloheximide Structure
Synonym:

Naramycin A; Actidione; CHX; FT 3422-2; NM-MCD 80

Size Price Availability Quantity
100mg USD 40  USD40 In stock
200mg USD 65  USD65 In stock
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Biological Activity

Cycloheximide (Naramycin A) is an eukaryote protein synthesis inhibitor, with IC50 values of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis (movement of two tRNA molecules and mRNA in relation to the ribosome) thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells studied in vitro (i.e. outside of organisms). It works rapidly. Its effects are rapidly reversed by simply removing it from the culture medium.

Product Citations
Customer Product Validations & Biological Datas
Source Biotechnol Lett (2018 Aug). Figure 3. cycloheximide (Abmole Bioscience)
Method Western blotting
Cell Lines Human embryonic kidney 293 cells
Concentrations 50 ug/mL
Incubation Time 3 h
Results The overexpression of UHRF2 shortened the half-life of p21 to 1 h compared to 3 h under controlled conditions.
Source Protein and Cell (2016). Figure 4.CHX (ABmole Bioscience, USA)
Method Half-life experiments
Cell Lines Human normal liver cells (LO2)
Concentrations 100 μg/mL
Incubation Time
Results Graph represents collated results rom three independent half-life experiments performed in HEK293, LO2 and HepG2 cells. TIP60 levels were normalized to 1 at time zero.
Chemical Information
Molecular Weight 281.35
Formula C15H23NO4
CAS Number 66-81-9
Solubility (25°C) DMSO ≥ 80 mg/mL
Water 15 mg/mL (ultrasonic and warming)
Storage 4°C, protect from light
References

[1] Teklebirhan G,et.al. Int J Microbiol. Prevalence of Dermatophytic Infection and the Spectrum of Dermatophytes in Patients Attending a Tertiary Hospital in Addis Ababa, Ethiopia.

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Keywords: Cycloheximide , Naramycin A; Actidione; CHX; FT 3422-2; NM-MCD 80 supplier, DNA/RNA Synthesis, inhibitors, activators

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