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COH-SR4 

Cat. No. M30552

All AbMole products are for research use only, cannot be used for human consumption.

COH-SR4  Structure

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Biological Activity

COH-SR4 is an AMPK activator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders.

Chemical Information
Molecular Weight 350.03
Formula C13H8Cl4N2O
CAS Number 73439-19-7
Form Solid
Solubility (25°C) DMSO 125 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kristen E Limbach, et al. Surgery. Baicalein activates 5' adenosine monophosphate-activated protein kinase, inhibits the mammalian target of rapamycin, and exhibits antiproliferative effects in pancreatic neuroendocrine tumors in vitro and in vivo

[2] James Lester Figarola, et al. PLoS One. COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice

[3] Sharad S Singhal, et al. Biochem Pharmacol. Novel compound 1,3-bis (3,5-dichlorophenyl) urea inhibits lung cancer progression

[4] James L Figarola, et al. Int J Mol Med. Small‑molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation

[5] Sharad S Singhal, et al. Biochem Pharmacol. 1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma

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Keywords: COH-SR4  supplier, AMPK, inhibitors, activators

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