cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.
|Solubility (25°C)||DMSO 46 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Dan-Dan Zhou, et al. Oxid Med Cell Longev. Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases
 Boxu Ren, et al. Cancer Lett. Resveratrol for cancer therapy: Challenges and future perspectives
 Johannes M Breuss, et al. Int J Mol Sci. Resveratrol and Its Effects on the Vascular System
 Ritu Kataria, et al. Curr Top Med Chem. Resveratrol in Various Pockets: A Review
 Sabina Galiniak, et al. Acta Biochim Pol. Health benefits of resveratrol administration
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