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Cat. No. M20776
cis-Resveratrol Structure

cis-RESV, cRes, (Z)-Resveratrol

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Biological Activity

cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.

Chemical Information
Molecular Weight 228.24
Formula C14H12O3
CAS Number 61434-67-1
Solubility (25°C) DMSO 46 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Dan-Dan Zhou, et al. Oxid Med Cell Longev. Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases

[2] Boxu Ren, et al. Cancer Lett. Resveratrol for cancer therapy: Challenges and future perspectives

[3] Johannes M Breuss, et al. Int J Mol Sci. Resveratrol and Its Effects on the Vascular System

[4] Ritu Kataria, et al. Curr Top Med Chem. Resveratrol in Various Pockets: A Review

[5] Sabina Galiniak, et al. Acta Biochim Pol. Health benefits of resveratrol administration

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Keywords: cis-Resveratrol, cis-RESV, cRes, (Z)-Resveratrol supplier, Nrf2, inhibitors, activators

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