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Ciprofloxacin hydrochloride

Cat. No. M10429
Ciprofloxacin hydrochloride Structure
Synonym:

CPX; Cetraxal; Ciloxan; Cipro; Bay-09867 hydrochloride

Size Price Availability Quantity
500mg USD 30  USD30 In stock
1g USD 45  USD45 In stock
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Quality Control & Documentation
Biological Activity

Ciprofloxacin hydrochloride is a β-diketone antibiotic with a broad spectrum antibacterial activity. Ciprofloxacin is an inhibitor of bacterial DNA gyrase (a subclass of Type II topoisomerases).

Chemical Information
Molecular Weight 367.8
Formula C17H18FN3O3.HCl
CAS Number 93107-08-5
Solubility (25°C) Water 12 mg/mL
DMSO 5 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] D M Campoli-Richards, et al. Dгυgs. Ciprofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use

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  Catalog
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Keywords: Ciprofloxacin hydrochloride, CPX; Cetraxal; Ciloxan; Cipro; Bay-09867 hydrochloride supplier, Antibiotic, inhibitors, activators


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