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Choline Fenofibrate

Cat. No. M20942
Choline Fenofibrate Structure
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Biological Activity

Choline fenofibrate is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist.

Chemical Information
Molecular Weight 421.91
Formula C22H28ClNO5
CAS Number 856676-23-8
Solubility (25°C) DMSO 5 mg/mL
Water 9 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Myung Soo Park, et al. Clin Ther. Efficacy and Safety of Fenofibrate-Statin Combination Therapy in Patients With Inadequately Controlled Triglyceride Levels Despite Previous Statin Monotherapy: A Multicenter, Randomized, Double-blind, Phase IV Study

[2] Sander Lefere, et al. J Hepatol. Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages☆

[3] No authors listed. Fenofibrate

[4] Mukul R Jain, et al. Liver Int. Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models

[5] Piyush Patel, et al. Indian J Endocrinol Metab. Comparison of efficacy and safety of choline fenofibrate (fenofibric acid) to micronized fenofibrate in patients of mixed dyslipidemia: A randomized, open-label, multicenter clinical trial in Indian population

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Keywords: Choline Fenofibrate supplier, PPAR, inhibitors, activators

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