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Chebulinic acid

Cat. No. M9118

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Chebulinic acid Structure
Synonym:

NSC69862

Size Price Availability Quantity
5mg USD 450  USD450 In stock
10mg USD 650  USD650 In stock
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Biological Activity

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity. Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. Chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml.

Chemical Information
Molecular Weight 956.68
Formula C41H32O27
CAS Number 18942-26-2
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Patel K, et al. Comput Biol Chem. Identification of chebulinic acid as potent natural inhibitor of M. tuberculosis DNA gyrase and molecular insights into its binding mode of action.

[2] Sivasankar S, et al. PLoS One. Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acid prevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation.

[3] Mishra V, et al. Phytomedicine. Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers.

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Keywords: Chebulinic acid, NSC69862 supplier, DNA/RNA Synthesis, inhibitors, activators

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