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Chaetoglobosin A

Cat. No. M11450
Chaetoglobosin A Structure
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Biological Activity

Chaetoglobosin A is an active ingredient in the extract of Penicillium aquamarinium and A member of cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells, thereby inducing cell cycle arrest and inhibiting membrane folds and cell migration.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 528.64
Formula C32H36N2O5
CAS Number 50335-03-0
Storage -20°C
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Keywords: Chaetoglobosin A supplier, Apoptosis, inhibitors

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