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Cat. No. M21370
Cefatrizine Structure

BL-S-640; SK&F 60771

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Biological Activity

Cefatrizine (BL-S-640) is an orally effective broad-spectrum cephalosporin antibiotic. Cefatrizine is used in cancer and bacterial infection research.

Chemical Information
Molecular Weight 462.5
Formula C18H18N6O5S2
CAS Number 51627-14-6
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] N Papantoniou, et al. Fetal Diagn Ther. Pharmacokinetics of oral cefatrizine in pregnant and non-pregnant women with reference to fetal distribution

[2] P J Santella, et al. Drugs Exp Clin Res. Cefatrizine: a clinical overview

[3] T Brotherton, et al. Antimicrob Agents Chemother. Susceptibility of Haemophilus influenzae type b to cefatrizine, ampicillin, and chloramphenicol

[4] P Actor, et al. Antimicrob Agents Chemother. Cefatrizine (SK&F 60771), a new oral cephalosporin: serum levels and urinary recovery in humans after oral or intramuscular administration--comparative study with cephalexin and cefazolin

[5] H C Neu, et al. Antimicrob Agents Chemother. Cefatrizine activity compared with that of other cephalosporins

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