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CDDO-2-P-Im

Cat. No. M11195
CDDO-2-P-Im Structure
Synonym:

CPD1589;CPDB1589

Size Price Availability Quantity
5mg USD 260  USD260 In stock
10mg USD 420  USD420 In stock
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Quality Control & Documentation
Biological Activity

Cddo-2p-im is a CDDO imidazolid analogue with chemoprophylaxis. Cddo-2p-im reduced the size and severity of lung tumors in mouse lung cancer models. Cddo-2p-im is an orally active necroptosis inhibitor that can be used in ischemia/reperfusion (I/R) studies.

Chemical Information
Molecular Weight 618.81
Formula C39H46N4O3
CAS Number 1883650-95-0
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: CDDO-2-P-Im, CPD1589;CPDB1589 supplier, Apoptosis, inhibitors, activators


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