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CB1-IN-1 is a novel potent restricted CB1R antagonist with Ki of 0.3 nM and 21 nM for CB1R and CB2R, respectively. CB1-IN-1 (BPRCB1184) possesses an extremely low brain to plasma ratio. CB1-IN-1 significantly improves insulin resistance in diabetic models, and induces weight loss and decreases hepatic steatosis as well as insulin resistance in obese model.
| Molecular Weight | 751.67 |
| Formula | C33H31Cl2F3N6O3S2 |
| CAS Number | 1429239-98-4 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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