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CADD522 is a novel small molecule inhibitor of RUNX2, downregulates RUNX2-mediated transcription of downstream target genes by inhibiting RUNX2-DNA binding, with an IC50 of 10 nM. The inhibition of the promoter-Luc activities of MMP13 in T47D-RUNX2 cells was almost completely blocked by CADD522 at 2 μM. The intraperitoneal (i.p.) administration of CADD522 into the MMTV-PyMT mice (up to 20 mg/kg) delayed tumor development and reduced tumor burden in transgenic MMTV-PyMT mice.
| Molecular Weight | 326.17 |
| Formula | C15H13Cl2NO3 |
| CAS Number | 199735-88-1 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage | 2-8°C, dry, protect from light, sealed |
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