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C8-Ceramide

Cat. No. M30569

All AbMole products are for research use only, cannot be used for human consumption.

C8-Ceramide Structure
Synonym:

N-Octanoyl-D-erythro-sphingosine

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Quality Control & Documentation
Biological Activity

C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro.

Chemical Information
Molecular Weight 425.69
Formula C26H51NO3
CAS Number 74713-59-0
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage -20°C, sealed
References

[1] Fangfang Liu, et al. BMC Mol Cell Biol. Ceramide induces pyroptosis through TXNIP/NLRP3/GSDMD pathway in HUVECs

[2] Marcela S Vera, et al. Exp Eye Res. Ceramide-1-phosphate promotes the migration of retina Müller glial cells

[3] Yuli C Chang, et al. Int J Mol Sci. Exogenous C₈-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells

[4] Huiqing Lv, et al. PLoS One. Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent

[5] Ambika T Singh, et al. Mol Cell Endocrinol. Ceramide biosynthesis and metabolism in trophoblast syncytialization

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Keywords: C8-Ceramide, N-Octanoyl-D-erythro-sphingosine supplier, Apoptosis, inhibitors, activators

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