Free shipping on all orders over $ 500

C-171

Cat. No. M20842
C-171 Structure
Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

C-171 is a covalent small-molecule inhibitor of STING. C-171 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING.

Chemical Information
Molecular Weight 316.35
Formula C17H20N2O4
CAS Number 2244881-69-2
Solubility (25°C) DMSO 63 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yupei Wang, et al. Front Genet. Three Variants Affecting Exon 1 of Ectodysplasin A Cause X-Linked Hypohidrotic Ectodermal Dysplasia: Clinical and Molecular Characteristics

[2] Yui Tada, et al. J Hum Genet. Comparison of two families with and without ataxia harboring novel variants in PRKCG

[3] Shuh Shing Lee, et al. Korean J Med Educ. Mobile learning in clinical settings: unveiling the paradox

[4] Bailing Zu, et al. Dev Dyn. Nonframeshifting indel variations in polyalanine repeat of HOXD13 gene underlies hereditary limb malformation for two Chinese families

[5] M Vishwanathan Padmaja, et al. Neurosci Lett. PARK2 gene mutations in early onset Parkinson's disease patients of South India

Related STING Products
STING agonist-30

STING agonist-30 is a potent STING agonist.

F-CRI1

F-CRI1 is a potent STING agonist with a Kd value of 40.62 nM.

STING agonist-31

STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING.

BI 7446

BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist.

STING agonist-8 dihydrochloride

STING agonist-8 dihydrochloride is a potent STING agonist with an EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells.

  Catalog
Abmole Inhibitor Catalog




Keywords: C-171 supplier, STING, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.