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C-171

Cat. No. M20842

All AbMole products are for research use only, cannot be used for human consumption.

C-171 Structure

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Quality Control & Documentation
Biological Activity

C-171 is a covalent small-molecule inhibitor of STING. C-171 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING.

Chemical Information
Molecular Weight 316.35
Formula C17H20N2O4
CAS Number 2244881-69-2
Solubility (25°C) DMSO 63 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yupei Wang, et al. Front Genet. Three Variants Affecting Exon 1 of Ectodysplasin A Cause X-Linked Hypohidrotic Ectodermal Dysplasia: Clinical and Molecular Characteristics

[2] Yui Tada, et al. J Hum Genet. Comparison of two families with and without ataxia harboring novel variants in PRKCG

[3] Shuh Shing Lee, et al. Korean J Med Educ. Mobile learning in clinical settings: unveiling the paradox

[4] Bailing Zu, et al. Dev Dyn. Nonframeshifting indel variations in polyalanine repeat of HOXD13 gene underlies hereditary limb malformation for two Chinese families

[5] M Vishwanathan Padmaja, et al. Neurosci Lett. PARK2 gene mutations in early onset Parkinson's disease patients of South India

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Keywords: C-171 supplier, STING, inhibitors, activators

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