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Budipine is an anti-parkinson agent. Budipine also is a substrate of P-glycoprotein (P-gp), is mediated the uptake into the brain by P-gp. Budipine also is N-methyl-d-aspartate (NMDA) antagonist, and has indirect dopaminergic effects through an improved dopamine release, the inhibition of monoamine oxidase type B (MAO-B). Budipine can be used for the research of CNS disorders include Parkinson disease.
| Molecular Weight | 293.45 |
| Formula | C21H27N |
| CAS Number | 57982-78-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 25 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Heinz Reichmann. J Neurol Sci. Budipine in Parkinson's tremor
[2] T Müller, et al. J Neural Transm (Vienna). Antiapoptotic effects of budipine
[5] H Przuntek, et al. J Neural Transm Suppl. Clinical efficacy of budipine in Parkinson's disease
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