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Brilliant Blue FCF

Cat. No. M13772
Brilliant Blue FCF Structure
Synonym:

Acid Blue 9; FD&C Blue No. 1; E133

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Quality Control & Documentation
Biological Activity

Brilliant Blue FCF has the appearance of a reddish-blue powder. It is soluble in water, and the solution has a maximum absorption at about 628 nanometers. It is a synthetic dye produced using aromatic hydrocarbons from petroleum, is a colorant for foods and other substances.

Chemical Information
Molecular Weight 792.85
CAS Number 3844-45-9
Solubility (25°C) Water 33.33 mg/mL (ultrasonic and adjust pH to 11 with NaOH)
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shirley H Bong, et al. Clin Gastroenterol Hepatol. A Brilliant Blue Liver

[2] Dawson B H Livingston, et al. Comp Biochem Physiol A Mol Integr Physiol. Active transport of brilliant blue FCF across the Drosophila midgut and Malpighian tubule epithelia

[3] Petra Amchova, et al. Regul Toxicol Pharmacol. Health safety issues of synthetic food colorants

[4] Kyle M Hocking, et al. J Vasc Surg. Brilliant blue FCF is a nontoxic dye for saphenous vein graft marking that abrogates response to injury

[5] Christos D Georgiou, et al. Anal Bioanal Chem. Mechanism of Coomassie brilliant blue G-250 binding to proteins: a hydrophobic assay for nanogram quantities of proteins

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Keywords: Brilliant Blue FCF, Acid Blue 9; FD&C Blue No. 1; E133 supplier, Fluorescent Dye, inhibitors, activators


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