Free shipping on all orders over $ 500

BMV109

Cat. No. M42840
BMV109 Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

BMV109 is a quenched probe that becomes fluorescent when cleaved and covalently bound by active cathepsin proteases.

Chemical Information
Molecular Weight 2138.37
Formula C107H108F4N10O23S5
CAS Number 1458731-58-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Abigail Anderson et al. bioRxiv. Loss of Progranulin Results in Increased Pan-Cathepsin Activity and Reduced LAMP1 Lysosomal Protein

[2] Heather Flanagan-Steet et al. Cell Rep. TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development

[3] Laura E Edgington-Mitchell et al. Methods Mol Biol. Live Cell Imaging and Profiling of Cysteine Cathepsin Activity Using a Quenched Activity-Based Probe

[4] Nimali P Withana et al. J Nucl Med. Dual-Modality Activity-Based Probes as Molecular Imaging Agents for Vascular Inflammation

[5] Steven Sensarn et al. Mol Imaging Biol. A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer

Related Fluorescent Dye Products
SOSG

SOSG (Singlet Oxygen Sensor Green Fluorescent Probe) is highly selective for singlet oxygen (1O2). It is commonly used for the detection of singlet oxygen in solutions and the evaluation of the efficacy of free radical scavengers.
FM1-43

FM1-43 is a very lipophilic, water-soluble styrene dyes, can specifically bind to cell membranes and inner membrane organelles to produce fluorescence. FM1-43 is widely used in endocytic and exospic membrane structure markers.
BCIP

BCIP is a chromogenic substrate for colorimetric assay of alkaline phosphatase activity.
MCA-SEVNLDAEFR-K(Dnp)-RR, amide

MCA-SEVNLDAEFR-K(Dnp)-RR, amide is a FRET-based substrate.
MeOSuc-AAPV-AMC

MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (Km: 362 μM, Ex=380 nm, Em=460 nm).
  Catalog
Abmole Inhibitor Catalog




Keywords: BMV109 supplier, Fluorescent Dye, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.