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BMS-986120

Cat. No. M21101

All AbMole products are for research use only, cannot be used for human consumption.

BMS-986120 Structure

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Quality Control & Documentation
Biological Activity

BMS-986120 is a first-in-class oral protease-activated receptor 4 (PAR4) inhibitor with IC50 values of 9.5 nM in human and 2.1 nM in monkey blood.BMS-986120 exhibits potent and selective antiplatelet effects. BMS-986120 has potent and selective antiplatelet effects and can be used in studies related to arterial thrombosis.

Chemical Information
Molecular Weight 513.59
Formula C23H23N5O5S2
CAS Number 1478712-37-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Samira Merali, et al. Platelets. New oral protease-activated receptor 4 antagonist BMS-986120: tolerability, pharmacokinetics, pharmacodynamics, and gene variant effects in humans

[2] E Scott Priestley, et al. J Med Chem. Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4

[3] Xiangying Yu, et al. Expert Opin Ther Pat. Inhibitors of protease-activated receptor 4 (PAR4): a review of recent patents (2013-2021)

[4] Panpan Chen, et al. Bioorg Med Chem. Synthesis and biological evaluation of BMS-986120 and its deuterated derivatives as PAR4 antagonists

[5] Simon J Wilson, et al. Arterioscler Thromb Vasc Biol. PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex Vivo Thrombus Formation

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  Catalog
Abmole Inhibitor Catalog




Keywords: BMS-986120 supplier, PAR, inhibitors, activators

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