All AbMole products are for research use only, cannot be used for human consumption.
BML-275 inhibits BMP signals required for embryogenesis and promoted significant neural differentiation from human pluripotent stem cell (hPSC) lines. BML-275 acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase); Ki = 109 nM in the presence of 5 μM ATP and the absence of AMP). BML-275 inhibited the cell proliferation of 4 human pancreatic cancer cell lines (MIA PaCa-2, Panc-1, Colo-357 and AsPC-1). In addition, BML-275 significantly increased the generation of intracellular reactive oxygen species (ROS), followed by induction of DNA damage signaling and apoptosis. Furthermore, BML-275 induced cell cycle arrest in the G2/M phase. BML-275 exerts its antitumor effects by inducing ROS generation, DNA damage and apoptosis via inhibition of the AMPK pathway and by inducing G2/M arrest via a pathway independent of AMPK, implicating its potential application as an antitumor agent for pancreatic cancer.
Int J Mol Sci. 2023 Jan 5;24(2):1070.
Sulforaphane Suppresses H2O2-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells
BML-275 purchased from AbMole
Italian Journal of Food Science. 2023 Apr 17;35 (2): 13–21.
Pretreatment of kaempferol-3-O-rutinoside protects H9c2 cells against LPS-induced inflammation through the AMPK/SIRT1 pathway
BML-275 purchased from AbMole
Int J Biol Sci. 2022 Jan 31;18(4):1594-1611.
Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway
BML-275 purchased from AbMole
Indian J Pharm Sci. 2022;2022:84(3)284-293.
Gallic acid Inhibits M1 Macrophage Polarization via Adenosine 5'-Monophosphate-Activated Protein Kinase/Signal Transducers and Activators of
BML-275 purchased from AbMole
J Cell Physiol. 2021 Mar;236(3):1889-1902.
Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARα/Sirt1/AMPKα pathway
BML-275 purchased from AbMole
BMC Cancer. 2020 Aug.
Blockage of AMPK-ULK1 pathway mediated autophagy promotes cell apoptosis to increase doxorubicin sensitivity in breast cancer (BC) cells: an in vitro study
BML-275 purchased from AbMole
| Molecular Weight | 399.49 |
| Formula | C24H25N5O |
| CAS Number | 866405-64-3 |
| Solubility (25°C) | DMSO 3 mg/mL warming |
| Storage | 2-8°C, protect from light |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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