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Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used for the research of topical pain reliever or in cough drops. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.
Benzocaine is topically applied to the following species: dogs, domestic shorthair cats, Long-Evans rats, Sprague-Dawley rats, ferrets, rhesus monkeys, cynomolgus monkeys, owl monkeys, New Zealand White rabbits, miniature pigs, ICR mice, C3H mice, and C57BL/10SnJ mice.
Molecular Weight | 165.19 |
Formula | C9H11NO2 |
CAS Number | 94-09-7 |
Solubility (25°C) | DMSO 85 mg/mL |
Storage | 4°C, protect from light |
[1] Syeda Khair-Ul-Bariyah, et al. Benzocaine: Review on a Drug with Unfold Potential
[2] Subrat Khanal, et al. Benzocaine-Associated Methemoglobinemia
[3] Michael R Kaufman, et al. Benzocaine-Induced Methemoglobinemia
[4] Jodi Lehr, et al. Benzocaine-induced methemoglobinemia in the pediatric population
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MS-222
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