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Bendazol

Cat. No. M20781
Bendazol Structure
Synonym:

2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan

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Quality Control & Documentation
Biological Activity

Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α.

Chemical Information
Molecular Weight 208.26
Formula C14H12N2
CAS Number 621-72-7
Solubility (25°C) DMSO 42 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Liyang Tong, et al. Ophthalmic Physiol Opt. Topical bendazol inhibits experimental myopia progression and decreases the ocular accumulation of HIF-1α protein in young rabbits

[2] Zhixia Huo, et al. J Sep Sci. Base-deactivated and alkaline-resistant chromatographic stationary phase based on functionalized polymethylsilsesquioxane microspheres

[3] Wali Khan, et al. Pak J Pharm Sci. Albendazole in the treatment of Hymenolepiasis in school children

[4] E V Eliseeva, et al. Bull Exp Biol Med. Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension

[5] E A Kuzubova, et al. Eksp Klin Farmakol. [Effect of dibazol (bendazol) on the generative function in rats]

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Keywords: Bendazol, 2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan supplier, NOS, inhibitors, activators


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