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Azure II

Cat. No. M22407
Azure II Structure
Size Price Availability Quantity
1g USD 25  USD25 In stock
5g USD 45  USD45 In stock
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Quality Control & Documentation
Biological Activity

Azure II

Chemical Information
Molecular Weight 625.68
Formula C16H18N3S.C15H16N3S.2Cl
CAS Number 37247-10-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] R E Coleman, et al. J Bone Oncol. Benefits and risks of adjuvant treatment with zoledronic acid in stage II/III breast cancer. 10 years follow-up of the AZURE randomized clinical trial (BIG 01/04)

[2] Kevser Biberoglu, et al. Chem Biol Interact. Azure B affects amyloid precursor protein metabolism in PS70 cells

[3] Mehdi Dastkhoon, et al. J Colloid Interface Sci. Magnetic based nanocomposite sorbent combination with ultrasound assisted for solid-phase microextraction of Azure II in water samples prior to its determination spectrophotometric

[4] Maryam Jafari, et al. J Colloid Interface Sci. Fixed-bed column performances of azure-II and auramine-O adsorption by Pinus eldarica stalks activated carbon and its composite with zno nanoparticles: Optimization by response surface methodology based on central composite design

[5] W Lhr, et al. Stain Technol. The azure dyes: their purification and physicochemical properties. II. Purification of azure B

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