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Astaxanthin is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3.
*This compound is unstable in solutions, freshly prepared is recommended.
J Nutr Biochem. 2025 Dec 01;149:110212.
Astaxanthin alleviates DSS-induced ulcerative colitis in mice associated with Nrf2-mediated ferroptosis independently of gut microbiota modulation.
Astaxanthin purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | HepG2 |
| Preparation method | HepG2 cells were seeded at a density of 0.15 × 10^6 cells/well into 24 well plates and incubated for 24 h. Cells were treated with 1 and 5 µM astaxanthin and incubated for an additional 24 h. |
| Concentrations | 1 and 5 µM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Female C57BL/6 and DBA/2 mice |
| Formulation | Medium chain triglyceride (MCT) |
| Dosages | 1 mg/kg/day |
| Administration | p.o. |
| Molecular Weight | 596.84 |
| Formula | C40H52O4 |
| CAS Number | 472-61-7 |
| Solubility (25°C) | DMF 1 mg/mL (Astaxanthin is usually formulated as a suspension) |
| Storage | -20°C, protect from light, dry, sealed |
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