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ASK1-IN-1 is a novel CNS-penetrant apoptosis signal-regulating kinase 1 (ASK1) inhibitor with good potency (cell IC50 = 138 nM), low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat K p,uu = 0.38).
| Molecular Weight | 405.41 |
| Formula | C19H19N9O2 |
| CAS Number | 2411382-24-4 |
| Form | Solid |
| Solubility (25°C) | Chloroform 5 mg/mL DMF 4 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related MAPKAPK2/MAP3K/MAP4K Products |
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| GNE-8505
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK). |
| TAK1-IN-3
TAK1-IN-3 is a potent ATP-competitive TAK1 inhibitor. |
| MSC 2032964A
MSC 2032964A is an orally active, selective inhibitor for apoptosis signal-regulating kinase 1(ASK1) with IC50 of 96 nM. |
| INS018 055
INS018 055 is a TNIK and MAP4K4 inhibitor with IC50 values of 12-120 nM, respectively. INS018 055 exhibits anti-fibrotic activity across different organs in vivo through oral, inhaled or topical administration. INS018 055 possesses anti-inflammatory effects in addition to its anti-fibrotic profile, validated in multiple in vivo studies. |
| MAP4K4-IN-3
MAP4K4-IN-3 is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, and an IC50 of 470 nM in cell assay. |
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