About 5 results found for searched term "ASK1-IN-1" (0.163 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9229 | GS-444217 | p38 MAPK |
| ASK1-IN-1 | ||
| GS-444217 is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87±0.85 nM. | ||
| M58401 | ASK1-IN-1 | MAPKAPK2/MAP3K/MAP4K |
| ASK1-IN-1 is a novel CNS-penetrant apoptosis signal-regulating kinase 1 (ASK1) inhibitor with good potency (cell IC50 = 138 nM), low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat K p,uu = 0.38). | ||
| M11042 | ASK1-IN-2 | Others |
| ASK1-IN-2 is a potent, orally active apoptosis signal-modulating kinase 1 (ASK1) inhibitor,IC50 The value is 32.8 nM. | ||
| M29868 | ZINC69391 | Ras |
| ZINC69391, a specific Rac1 inhibitor, interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. ZINC69391 interferes with the interaction of Rac1 with Dock180 and reduces Rac1-GTP levels. ZINC69391 induces apoptosis, and shows antiproliferative and antimetastatic effects. | ||
| M42131 | ASK1-IN-4 | MAPKAPK2/MAP3K/MAP4K |
| ASK1-IN-4 is an ASK1 inhibitor (IC50=0.2 μM). | ||
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