Inhibitor
| Cat.No. | Name | Information |
|---|---|---|
| M54852 | MAP4K4-IN-3 | MAP4K4-IN-3 is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, and an IC50 of 470 nM in cell assay. |
| M20578 | PF-6260933 | PF-6260933 is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity. |
| M9342 | NG25 | NG25 is a potent dual TAK1 and MAP4K2 inhibitor with IC50s of 149 nM and 21.7 nM, respectively. |
| M9015 | GNE-495 | GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM. |
| M6310 | Takinib | Takinib is a potent and selective TAK1 inhibitor with an IC50 of 9.5 nM, more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively. |
| M43425 | PROTAC MLKL Degrader-1 | PROTAC MLKL Degrader-1 is a PROTAC degrader of MLKL, with a Dmax ＞90%. |
| M42140 | HPK1-IN-37 | HPK1-IN-37 is an inhibitor of HPK1 (IC50=3.7 nM). |
| M42139 | GNE-6893 | GNE-6893 is a potent and orally active HPK1 inhibitor. |
| M42138 | HPK1-IN-39 | HPK1-IN-39 is a selective HPK1 Inhibitor (IC50: 29 nM). |
| M42137 | HPK1-IN-36 | HPK1-IN-36 is a potent HPK1 inhibitor with an IC50 value of 0.5 nM. |
| M42136 | HPK1-IN-35 | HPK1-IN-35 is a potent and selective HPK1 inhibitor with an IC50 value of 3.5 nM. |
| M42135 | HPK1-IN-38 | HPK1-IN-38 is a MAP4K1/HPK1 inhibitor, can be used for HPK1 related disorders research. |
| M42134 | HPK1-IN-34 | HPK1-IN-34 is a Hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of <100 nM. |
| M42133 | HPK1-IN-33 | HPK1-IN-33 is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a Ki value of 1.7 nM. |
| M42132 | TNIK&MAP4K4-IN-1 | TNIK&MAP4K4-IN-1 is a dual inhibitor of TNIK and MAP4K4/HGK with IC50s of 1.29 nM and <10 nM, respectively, in human hepaticstellate cell LX-2. |
| M42131 | ASK1-IN-4 | ASK1-IN-4 is an ASK1 inhibitor (IC50=0.2 μM). |
| M42130 | AZ-TAK1 | AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines. |
| M42129 | IACS-52825 | IACS-52825 is a potent and selective DLK inhibitor with Kd of 1.3 nM, useful for the study of chemotherapy-induced peripheral neuropathy. |
| M29187 | SM1-71 | SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines. |
| M28703 | TL4-12 | TL4-12 is a selective MAP4K2/GCK inhibitor, dose-dependently downregulates IKZF1 and BCL-6 and leads to MM cell proliferation inhibition (IC50=37 nM) accompanied by induction of apoptosis. TL4-12 can be used to overcome immunomodulatory agent resistance in multiple myeloma (MM). |
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