Inhibitor
| Cat.No. | Name | Information |
|---|---|---|
| M58401 | ASK1-IN-1 | ASK1-IN-1 is a novel CNS-penetrant apoptosis signal-regulating kinase 1 (ASK1) inhibitor with good potency (cell IC50 = 138 nM), low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat K p,uu = 0.38). |
| M54852 | MAP4K4-IN-3 | MAP4K4-IN-3 is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, and an IC50 of 470 nM in cell assay. |
| M20578 | PF-6260933 | PF-6260933 is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity. |
| M9342 | NG25 | NG25 is a potent dual TAK1 and MAP4K2 inhibitor with IC50s of 149 nM and 21.7 nM, respectively. |
| M9015 | GNE-495 | GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM. |
| M6310 | Takinib | Takinib is a potent and selective TAK1 inhibitor with an IC50 of 9.5 nM, more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively. |
| M56434 | GNE-8505 | GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK). |
| M56433 | TAK1-IN-3 | TAK1-IN-3 is a potent ATP-competitive TAK1 inhibitor. |
| M56432 | MSC 2032964A | MSC 2032964A is an orally active, selective inhibitor for apoptosis signal-regulating kinase 1(ASK1) with IC50 of 96 nM. |
| M55626 | INS018 055 | INS018 055 is a TNIK and MAP4K4 inhibitor with IC50 values of 12-120 nM, respectively. INS018 055 exhibits anti-fibrotic activity across different organs in vivo through oral, inhaled or topical administration. INS018 055 possesses anti-inflammatory effects in addition to its anti-fibrotic profile, validated in multiple in vivo studies. |
| M43425 | PROTAC MLKL Degrader-1 | PROTAC MLKL Degrader-1 is a PROTAC degrader of MLKL, with a Dmax ＞90%. |
| M42140 | HPK1-IN-37 | HPK1-IN-37 is an inhibitor of HPK1 (IC50=3.7 nM). |
| M42139 | GNE-6893 | GNE-6893 is a potent and orally active HPK1 inhibitor. |
| M42138 | HPK1-IN-39 | HPK1-IN-39 is a selective HPK1 Inhibitor (IC50: 29 nM). |
| M42137 | HPK1-IN-36 | HPK1-IN-36 is a potent HPK1 inhibitor with an IC50 value of 0.5 nM. |
| M42136 | HPK1-IN-35 | HPK1-IN-35 is a potent and selective HPK1 inhibitor with an IC50 value of 3.5 nM. |
| M42135 | HPK1-IN-38 | HPK1-IN-38 is a MAP4K1/HPK1 inhibitor, can be used for HPK1 related disorders research. |
| M42134 | HPK1-IN-34 | HPK1-IN-34 is a Hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of <100 nM. |
| M42133 | HPK1-IN-33 | HPK1-IN-33 is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a Ki value of 1.7 nM. |
| M42132 | TNIK&MAP4K4-IN-1 | TNIK&MAP4K4-IN-1 is a dual inhibitor of TNIK and MAP4K4/HGK with IC50s of 1.29 nM and <10 nM, respectively, in human hepaticstellate cell LX-2. |
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