Inhibitor
| Cat.No. | Name | Information |
|---|---|---|
| M28107 | PF-3644022 | PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect. |
| M21398 | 7,3',4'-Trihydroxyisoflavone | 7,3',4'-Trihydroxyisoflavone is the main metabolite of soybean sapogenins and is a competitive inhibitor of ATP for Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, antiangiogenic, chemoprotective and free radical scavenging activities. |
| M20713 | DMX-5084 | DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively. |
| M14165 | MK2-IN-1 hydrochloride | MK2-IN-1 hydrochloride is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode. |
| M14163 | Cot inhibitor-2 | Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM. |
| M10832 | HPK1-IN-7 | HPK1-IN-7 is a potent inhibitor of the orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) (IC50=2.6 nM), with excellent family and kinase group selectivity. The HPK1-IN-7 is selective for IRAK4 (59 nM) and GLK (140 nM). HPK1-IN-7 combined with anti-PD1 has shown powerful efficacy in MC38 cogenic tumor models. |
| M10831 | HPK1-IN-3 | HPK1-IN-3 is a potent selective ATP competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor,IC50 0.25 nM. HPK1-IN-3 has IL-2 cell potency, EC in human peripheral blood mononuclear cells (PBMCs).50 108 nM. |
| M7391 | TC-S 7006 | TC-S 7006 is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
