Inhibitor
| Cat.No. | Name | Information |
|---|---|---|
| M42131 | ASK1-IN-4 | ASK1-IN-4 is an ASK1 inhibitor (IC50=0.2 μM). |
| M42130 | AZ-TAK1 | AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines. |
| M42129 | IACS-52825 | IACS-52825 is a potent and selective DLK inhibitor with Kd of 1.3 nM, useful for the study of chemotherapy-induced peripheral neuropathy. |
| M29187 | SM1-71 | SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines. |
| M28703 | TL4-12 | TL4-12 is a selective MAP4K2/GCK inhibitor, dose-dependently downregulates IKZF1 and BCL-6 and leads to MM cell proliferation inhibition (IC50=37 nM) accompanied by induction of apoptosis. TL4-12 can be used to overcome immunomodulatory agent resistance in multiple myeloma (MM). |
| M28107 | PF-3644022 | PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect. |
| M21398 | 7,3',4'-Trihydroxyisoflavone | 7,3',4'-Trihydroxyisoflavone is the main metabolite of soybean sapogenins and is a competitive inhibitor of ATP for Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, antiangiogenic, chemoprotective and free radical scavenging activities. |
| M20713 | DMX-5084 | DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively. |
| M14165 | MK2-IN-1 hydrochloride | MK2-IN-1 hydrochloride is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode. |
| M14163 | Cot inhibitor-2 | Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM. |
| M10832 | HPK1-IN-7 | HPK1-IN-7 is a potent inhibitor of the orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) (IC50=2.6 nM), with excellent family and kinase group selectivity. The HPK1-IN-7 is selective for IRAK4 (59 nM) and GLK (140 nM). HPK1-IN-7 combined with anti-PD1 has shown powerful efficacy in MC38 cogenic tumor models. |
| M10831 | HPK1-IN-3 | HPK1-IN-3 is a potent selective ATP competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor,IC50 0.25 nM. HPK1-IN-3 has IL-2 cell potency, EC in human peripheral blood mononuclear cells (PBMCs).50 108 nM. |
| M7391 | TC-S 7006 | TC-S 7006 is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor. |
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