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HPK1-IN-7 is a potent inhibitor of the orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) (IC50=2.6 nM), with excellent family and kinase group selectivity. The HPK1-IN-7 is selective for IRAK4 (59 nM) and GLK (140 nM). HPK1-IN-7 combined with anti-PD1 has shown powerful efficacy in MC38 cogenic tumor models.
| Molecular Weight | 458.47 |
| Formula | C24H22N6O4 |
| CAS Number | 2320462-65-3 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related MAPKAPK2/MAP3K/MAP4K Products |
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ASK1-IN-1 is a novel CNS-penetrant apoptosis signal-regulating kinase 1 (ASK1) inhibitor with good potency (cell IC50 = 138 nM), low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat K p,uu = 0.38). |
| GNE-8505
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK). |
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TAK1-IN-3 is a potent ATP-competitive TAK1 inhibitor. |
| MSC 2032964A
MSC 2032964A is an orally active, selective inhibitor for apoptosis signal-regulating kinase 1(ASK1) with IC50 of 96 nM. |
| INS018 055
INS018 055 is a TNIK and MAP4K4 inhibitor with IC50 values of 12-120 nM, respectively. INS018 055 exhibits anti-fibrotic activity across different organs in vivo through oral, inhaled or topical administration. INS018 055 possesses anti-inflammatory effects in addition to its anti-fibrotic profile, validated in multiple in vivo studies. |
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