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MAP4K4-IN-3 is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, and an IC50 of 470 nM in cell assay.
| Molecular Weight | 297.74 |
| Formula | C15H12ClN5 |
| CAS Number | 1811510-58-3 |
| Solubility (25°C) | DMSO 9 mg/mL |
| Storage | 4°C, protect from light |
| Related MAPKAPK2/MAP3K/MAP4K Products |
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(R)-Zunsemetinib is the isomer of Zunsemetinib, it can be used as an experimental control. Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. |
| ASK1-IN-1
ASK1-IN-1 is a novel CNS-penetrant apoptosis signal-regulating kinase 1 (ASK1) inhibitor with good potency (cell IC50 = 138 nM), low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat K p,uu = 0.38). |
| GNE-8505
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK). |
| TAK1-IN-3
TAK1-IN-3 is a potent ATP-competitive TAK1 inhibitor. |
| MSC 2032964A
MSC 2032964A is an orally active, selective inhibitor for apoptosis signal-regulating kinase 1(ASK1) with IC50 of 96 nM. |
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