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TL4-12 is a selective MAP4K2/GCK inhibitor, dose-dependently downregulates IKZF1 and BCL-6 and leads to MM cell proliferation inhibition (IC50=37 nM) accompanied by induction of apoptosis. TL4-12 can be used to overcome immunomodulatory agent resistance in multiple myeloma (MM).
| Molecular Weight | 500.52 |
| Formula | C25H27F3N6O2 |
| CAS Number | 1620820-12-3 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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