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PF-3644022 

Cat. No. M28107

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PF-3644022  Structure

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Quality Control & Documentation
Biological Activity

PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect.

Chemical Information
Molecular Weight 374.46
Formula C21H18N4OS
CAS Number 1276121-88-0
Form Solid
Solubility (25°C) DMSO 41.67 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lei Yu, et al. Ann Palliat Med. Role of MK2 signaling pathway mediating microglia/macrophages polarization in chronic compression injury of cervical spinal cord

[2] Kiersten L Berggren, et al. Oncogene. MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma

[3] Yizhu Li, et al. Cancer Lett. Inhibition of MAPKAPK2/MK2 facilitates DNA replication upon cancer cell treatment with gemcitabine but not cisplatin

[4] Hongxing Song, et al. Am J Transl Res. Role of MK2 signaling pathway in the chronic compression of cervical spinal cord

[5] Robert J Mourey, et al. J Pharmacol Exp Ther. A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation

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  Catalog
Abmole Inhibitor Catalog




Keywords: PF-3644022  supplier, MAPKAPK2/MAP3K/MAP4K, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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