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ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etoposide (IC50=120 μM). ARN-21934 exhibits a favorable in vivo pharmacokinetic profile and is a promising lead compound for anticancer research.
| Molecular Weight | 360.46 |
| Formula | C21H24N6 |
| CAS Number | 2230854-93-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 8.33 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | Powder -20°C |
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